Our work so far...

 MyNCMBI for Michael Riehle




MyNCBI for Dr. Michael Riehle
  1. Guzmán L, Wijetunge AN, Riske BF, Massani BB, Riehle MA, Jewett JC. Chemical probes to interrogate the extreme environment of mosquito larvae guts. Journal of the American Chemical Society. DOI: 10.1021/jacs.3c14598
  2. Isoe J, Simington CJ, Oscherwitz ME, Peterson AJ, Rascón AA, Massani BB, Miesfeld RL, Riehle MA. Characterization of essential eggshell proteins from Aedes aegypti mosquitoes. BMC biology. 21(1):1-24. (2023)
  3. Riske BF, Luckhart S, Riehle MA. Starving the Beast: Limiting Coenzyme A Biosynthesis to Prevent Disease and Transmission in Malaria. International Journal of Molecular Sciences. 24(18):13915. (2023)
  4. Isoe J, Riehle MA, Miesfeld RL. Mosquito egg development and eggshell formation. Cold Spring Harbor Laboratory Press. (2023)
  5. Isoe J, Parsawar K, David CL, Riehle MA, Miesfeld RL. Identification of mosquito eggshell proteins from Aedes aegypti by liquid chromatography with tandem mass sectrometry (LC-MS/MS) proteomic analysis. Cold Spring Harbor Laboratory Press. (2023)
  6. Isoe J, Miesfeld RL, Riehle MA. Visualization of apoptotic ovarian follicles during Aedes aegypti mosquito egg maturation by fluorescent imaging studies. Cold Spring Harbor Laboratory Press. (2023)
  7. Ernst KC, Walker KR, Castro-Luque AL, Schmidt C, Joy TK, Brophy M, Reyes-Castro P, Díaz-Caravantes RE, Encinas VO, Aguilera A, Gameros M, Cuevas Ruiz RE, Hayden MH, Alvarez G, Monaghan A, Williamson D, Arnbrister J, Gutiérrez EJ, Carrière Y, Riehle MA. Differences in Longevity and Temperature-Driven Extrinsic Incubation Period Correlate with Varying Dengue Risk in the Arizona–Sonora Desert Region. Viruses. 15(4):851. (2023)
  8. Gutiérrez EH, Riehle MA, Walker KR, Ernst KC, Davidowitz G. Using body size as an indicator for age structure in field populations of Aedes aegypti (Diptera: Culicidae). Parasites & Vectors. 15(1): 1-5. (2022)
  9. Thakre N, Gurge RM, Isoe J, Kivi H, Strickland J, Delacruz LR, Rodriguez AM, Haney R, Sadeghi R, Joy T, Chen M, Luckhart S, Riehle MA. Manipulation of pantothenate kinase in Anopheles stephensi suppresses pantothenate levels with minimal impacts on mosquito fitness. Insect Biochemistry and Molecular Biology. 149. (2022)
  10. Joy T, Chen M, Arnbrister J, Williamson D, Li S, Nair S, Brophy M, Garcia VM, Walker K, Ernst K, Gouge DH, Carrière Y, Riehle MA. Assessing Near-Infrared Spectroscopy (NIRS) for Evaluation of Aedes aegypti Population Age Structure. Insects. 2022; 13(4):360.
  11. Brophy M, Riehle MA, Mastrud N, Ravenscraft A, Adamson JE, Walker KR. Genetic Variation in Rhipicephalus sanguineus s.l. Ticks across Arizona. Int. J. Environ. Res. Public Health. 19, 4223. (2022)
  12. Hun LV, Cheung KW, Brooks E, Zudekoff R, Luckhart S, Riehle MA. Increased insulin signaling in the Anopheles stephensi fat body regulates metabolism and enhances the host response to both bacterial challenge and Plasmodium falciparum infection, Insect Biochemistry and Molecular Biology. (2021)
  13. Simão-Gurge RM, Thakre N, Strickland J, Isoe J, Delacruz LR, Torrevillas BK, Rodriguez AM, Riehle MA, & Luckhart S. Activation of Anopheles stephensi pantothenate kinase and coenzyme A biosynthesis reduces infection with diverse Plasmodium species in the mosquito host. Biomolecules. (2021)
  14. Oringanje, C., Delacruz, LR., Han, Y., Luckhart, S., & Riehle, MA. Overexpression of activated AMPK in the Anopheles stephensi midgut impacts mosquito metabolism, reproduction and Plasmodium resistance. Genes, 12(1), 119. (2021)
  15. Luckhart, S., & Riehle, MA. Midgut mitochondrial function as a gatekeeper for malaria parasite infection and development in the mosquito host. Frontiers in Cellular and Infection Microbiology, 10. (2020)
  16. Comeau, G., Zinna, RA., Scott, T., Ernst, K., Walker, K., Carrière, Y., & Riehle, MA. Vertical transmission of Zika virus in Aedes aegypti produces potentially infectious progeny. The American journal of tropical medicine and hygiene, 103(2), 876-883. (2020)
  17. Jeffrey Gutiérrez EH, Walker KR, Ernst KC, Riehle MA, Davidowitz G. Size as a Proxy for Survival in Aedes aegypti (Diptera: Culicidae) Mosquitoes. Journal of Medical Entomology. (2020)
  18. Hun, L., Luckhart, S. and Riehle, M.A. Increased Akt signaling in the fat body of Anopheles stephensi extends lifespan and increases lifetime fecundity through modulation of insulin-like peptides. Journal of insect physiology, p.103932. (2019)
  19. Souvannaseng, L., Hun, L.V., Baker, H., Klyver, J.M., Wang, B., Pakpour, N., Bridgewater, J.M., Napoli, E., Giulivi, C., Riehle, M.A. and Luckhart, S. Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection. PLoS pathogens, 14(11), p.e1007418. (2018)
  20. Ernst, K.C., Walker, K.R., Reyes-Castro, P., Joy, T.K., Castro-Luque, A.L., Diaz-Caravantes, R.E., Gameros, M., Haenchen, S., Hayden, M.H., Monaghan, A., Jeffrey-Guttierez, E., Carrière Y., and Riehle, M.A. Aedes aegypti (Diptera: Culicidae) Longevity and Differential Emergence of Dengue Fever in Two Cities in Sonora, Mexico. Journal of Medical Entomology, 54(1), pp.204-211. (2017)
  21. Luckhart, S. and Riehle, M.A. Conservation and convergence of immune signaling pathways with mitochondrial regulation in vector arthropod physiology. In Arthropod Vector: Controller of Disease Transmission, Volume 1 (pp. 15-33). Academic Press. (2017)
  22. Pietri, J.E., Pakpour, N., Napoli, E., Song, G., Pietri, E., Potts, R., Cheung, K.W., Walker, G., Riehle, M.A., Starcevich, H. and Giulivi, C. Two insulin-like peptides differentially regulate malaria parasite infection in the mosquito through effects on intermediary metabolism. Biochemical Journal, 473(20), pp.3487-3503. (2016)
  23. Klionsky, Daniel J., et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 12.1: 1-222. (2016)
  24. Pietri J.E., Pietri E.J., Potts R., Riehle M.A. & Luckhart S. Plasmodium falciparum suppresses the host immune response by inducing the synthesis of insulin-like peptides (ILPs) in the mosquito Anopheles stephensi. Developmental & Comparative Immunology, 53(1), 134-144. (2015).
  25. Johnson, A. A., & Riehle, M. A. Resveratrol Fails to Extend Life Span in the Mosquito Anopheles stephensi. Rejuvenation research, 18(5), 473-478. (2015).
  26. Arik A.J., Hun L.V., Quicke K., Piatt M., Ziegler R., Scaraffia P.Y., Badgandi H., Riehle M.A. Increased Akt signaling in the mosquito fat body increases adult survivorship. FASEB J. 29(4): 1404-1413. (2015)
  27. Neafsey D.E., et al. Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes. Science. 347(6217): 43. (2015)
  28. Pakpour N., Riehle M.A., Luckhart S., Effects of ingested vertebrate-derived factors on insect immune responses. Current Opinion in Insect Science. 3:1-5 (2014)
  29. Xiaofang Jiang, Ashley Peery, A. Brantley Hall, Atashi Sharma, Xiao-Guang Chen, Robert M. Waterhouse, Aleksey Komissarov, Michelle M. Riehle, Yogesh Shouche, Maria V. Sharakhova, Dan Lawson, , Nazzy Pakpour, Peter Arensburger, Victoria L. M. Davidson, Karin Eiglmeier, Scott Emrich, Phillip George, Ryan C. Kennedy, Shrinivasrao P. Mane, Gareth Maslen, Chioma Oringanje, Yumin Qi, Robert Settlage, Marta Tojo, Jose M. C. Tubio, Maria F. Unger, Bo Wang, Kenneth D. Vernick, Jose M. C. Ribeiro, Anthony A. James, Kristin Michel, Michael A. Riehle, Shirley Luckhart, Igor V. Sharakhov, Zhijian Tu. (2014) Genome analysis of a major urban malaria vector mosquito, Anopheles stephensi. Genome Biology.
  30. Drexler AL., Pietri JE., Pakpour N., Hauck E., Wand B., Glennon EKK., Georgis M., Riehle MA., Luckhart S. Human IGF1 regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi. PLoS Pathog 10(6): e1004231. DOI: 10.1371/journal.ppat.1004231. (2014)
  31. International Glossina Genome Initiative. Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis. Science. 344(6182): 380-386 (2014)
  32. Hauck ES., Antonova-Koch Y., Drexler A., Pietri J., Pakpour N., Liu D., Blacutt J., Riehle MA., Luckhart S. Overexpression of phosphatase and tensin homolog improves fitness and decreases Plasmodium falciparum development in Anopheles stephensi. Microbes and Infection. doi: 10.1016/j.micinf.2013.05.006. (2013)
  33. Luckhart S., Giulivi C., Drexler A.L., Antonova-Koch Y., Sakaguchi D., Napoli E., Wong S., Price M.S., Eigenheer R., Phinney B.S., Pakpour N., Pietri J.E., Cheung K., Georgis M., and Riehle M.A. Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito most. PLoS Pathog 9(2): e1003180. doi:10.1371/journal.ppat.1003180. (2013)
  34. Antonova-Koch Y., Riehle M.A., Arik A.J. and Brown M.R. Insulin-Like Peptides. In Handbook of Biologically Active Peptides: Invertebrate Peptides. (2013).
  35. Joy T.K., Jeffrey Gutierrez E.H., Ernst K., Walker K.R., Carriere Y., Torabi M., Riehle M.A. Aging field collected Aedes aegypti to determine their capacity for dengue transmission in the Southwestern United States. PLoS One 10.1371/journal.pone.0046946 (2012)
  36. Pakpour N., Corby-Harris V. †, Green G., Smithers H., Cheung K., Riehle M.A., and Luckhart S. Ingested human insulin inhibits the mosquito NF-κB-dependent immune response to Plasmodium falciparum. Infection and Immunity. 80(6):2141-9. (2012)
  37. Antonova Y., Arik A.J., Moore W, Riehle M.A., and Brown M.R. Insulin-like peptides: Structure, signaling, and function. In Gilbert L.I. (Ed) Insect Endocrinology (pp. 63-92). Academic Press. (2012) 
  38. Marquez A.G., Pietri J.E., Smithers H.M., Nuss A., Antonova Y. †, Drexler A.L., Riehle M.A., Brown M.R., and Luckhart S.L. Insulin-like peptides in the mosquito Anopheles stephensi: identification and expression in response to diet and infection with Plasmodium falciparum. General and Comparative Endocrinology. 173(2). 303-12. (2011)
  39. Ziegler R., Isoe J., Moore W., Riehle M.A., and Wells M.A. The putative AKH receptor of Manduca sexta and its expression in fat body during development. Journal of Insect Science. (2011)
  40. Corby-Harris V., Drexler A., Watkins de Jong L., Antonova Y., Pakpour N., Ziegler R., Ramberg F., Lewis E.E., Brown J.M, Luckhart S., and Riehle M.A.  Activation of Akt signaling reduces the prevalence and intensity of malaria parasite infection and lifespan in Anopeheles stephensi mosquitoes.  PLoS Pathogens. 6(7). e1001003 (2010)
  41. Joy T, Corby-Harris V., Johnson A., and Riehle M.A. The impact of larval and adult dietary restriction on lifespan and reproduction in the mosquito Aedes aegypti. Experimental Gerontology. 45(9). 685-690 (2010)
  42. Baker P.B., Hagler J.R., Marchosky R., Machtley S.A., Brown J.M., Riehle M.A., and Bellamy D.E.  Utilizing rabbit immunoglobulin G (IgG) protein for mark-capture studies on the desert subterranean termite, Heterotermes aureus (Snyder).  Insectes Sociaux. 57(2). 147. (2010)
  43. Arik A.J., Rasgon J.L., Quicke K.M., and Riehle M.A.  Manipulating insulin signaling to enhance mosquito reproduction: A possible genetic drive mechanism?  BMC Physiology. 9. (2009)
  44. Pri-Tal B., Brown J.M., and Riehle M.A. Identification and characterization of the catalytic subunit of phosphatidylinositol 3-kinase in the yellow fever mosquito Aedes aegypti. Insect Biochemistry and Molecular Biology. 38(10). 932-9. (2008)
  45. Rodrigues F.G., De Carvalho T.X.T., Rocha B.C., Riehle M.A., Pimenta P.F.P., Jacobs-Lorena M., Alves de Brito C.F., and Moreira L.A. Expression of a mutated phospholipase A2 in transgenic Aedes fluviatilis mosquitoes towards Plasmodium gallinaceum. Insect Biochemistry and Molecular Biology. 17(2).175-83. (2008).
  46. Luckhart S, and Riehle M.A. The insulin signaling cascade from nematodes to mammals: Insights into innate immunity of Anopheles mosquitoes to malaria parasite infection. Dev Comp Immunol. 31(7). 647-56. (2007).
  47. Riehle M.A., Moreira C.K., Lampe D., Lauzon C., and Jacobs-Lorena M. Using bacteria to express and display anti-Plasmodium molecules in the mosquito midgut. International Journal of Parasitology. 37(6). 595-603. (2007).
  48. Riehle M.A. & Brown J.M. Identification and characterization of six Phosphatase and Tensin Homolog (PTEN) splice variants from the mosquito Aedes aegypti. Insect Mol Biol. 16(3). 277-86. (2007).
  49. Riehle M.A., Fan Y, Cao C, and Brown MR. Molecular cloning and tissue localization of insulin-like peptides in the yellow fever mosquito, Aedes aegypti. Peptides. 27(11). 2547-60 (2006).
  50. Riehle M.A. and Jacobs-Lorena M. Using bacteria to express and display anti-parasite molecules in mosquitoes: current and future strategies. Insect Biochemistry and Molecular Biology.  35(7). 699-707. (2005)
  51. Krieger M.J.B., Jahan N., Riehle M.A., Cao C., and Brown M.R. Molecular characterization of insulin-like peptide genes and their expression in the African malaria mosquito, Anopheles gambiae.  Insect Molecular Biology. 13(3). 305-315. (2004)
  52. Riehle M.A., Sriniva P., Moreira C.K., And Jacobs-Lorena M. Towards genetic manipulation of wild mosquito populations to combat malaria: advances and challenges.  Journal of Experimental Biology.  206, 3809-3816. (2003).
  53. Riehle M.A. and Brown M.R. Molecular analysis of the serine/threonine kinase Akt in the female mosquito Aedes aegypti.  Insect Molecular Biology. 12(3). 225-232. (2003).
  54. Riehle M.A., Seagraves M., AND Pettis G.  Releasing insects that have been genetically modified to be incapable of vectoring human diseases is safe and ethical. A student debate.  American Entomologist. 49(1).  45-46. (2003)
  55. Riehle M.A., Garczynski S.F., Crim J.W., Hill C.A., and Brown M.R. Neuropeptides and peptide hormones in Anopheles gambiae.  Science.  298. 172-175. (2002)
  56. Riehle, M.A. and Brown, M.R.  Insulin receptor expression during development and a reproductive cycle in the ovary of the mosquito Aedes aegypti.  Cell and Tissue Research. 308(3).  409-420. (2002)
  57. Stracker T.H, Thompson, S. Grossman, G.L, Riehle M.A., and Brown M.A.  Characterization of the AeaHP gene and its expression in the mosquito Aedes aegypti.  Journal of Medical Entomology.  39(2). 331-342. (2002)
  58. Riehle, M. and Brown, M.R.  Insulin stimulates ecdysteroid production through a conserved signaling cascade in the mosquito Aedes aegypti.  Insect Biochemistry and Molecular Biology. 29. 855-860. (1999).
  59. Paskewitz, S. and Riehle, M.  A factor preventing melanization of Sephadex CM C-25 beads in Plasmodium-susceptible and refractory Anopheles gambiae.  Experimental Parasitology.  90.  34-41. (1998).
  60. Riehle, M. and Paskewitz, S. Ixodes scapularis (Acari: Ixodidae): Status and changes in prevalence and distribution in Wisconsin between 1981 and 1994 measured by deer surveillance. Journal of Medical Entomology. 33(6).  933- 938. (1996)
  61. Whitaker, P., Chenot, A., Riehle, M., and Voss, K. Has the US been negligent in regulating the Importation, release, and use of generalist natural enemies: in Environmental issues associated with enhancing the impact of biological control agents: a student debate. American Entomologist.  42(3).  160-173. (1996).
  62. Chun, J., Riehle, M., and Paskewitz, S.M. Effect of mosquito age and reproductive status on melanization of Sephadex beads in Plasmodium-refractory and susceptible strains of Anopheles gambiae. Journal of Invertebrate Pathology. 66. 11-17. (1995)
  63. Paskewitz, S.M. and Riehle, M.A. Response of Plasmodium-refractory and susceptible strains of Anopheles gambiae to inoculated Sephadex beads. Devel. Comp. Immunol. 18(5). 369-375. (1994)